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Protein and Amino Acid Metabolism 26

Results and discussion Primary fragment screening by X-ray crystallography Due to its broad affinity detection range (nanomolar to millimolar) and unique ability to initiate rational drug design 30 , we carried out a crystallographic fragment screen against TRF1 TRFH at the XChem facility of the Diamond Light Source 30

464 Notably, the carotid body expresses GLP-1R, which is implicated in the concurrent regulation of blood pressure and blood glucose
