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Nucleic Acids Res 48 , 52355253 (2020)
Conversely, overexpression of GCLC or GPX4 in CD8 T cells enhances their antitumor capacity, confirming that equipping (CAR) T cells with enhanced redox resistance is beneficial for improving cancer immunotherapy

Arrowhead Pharmaceuticals

Figure 2 2.1.1 Pro-ferroptotic drivers: ACSL4 and iron Acyl-CoA synthetase long-chain family member 4 (ACSL4) is key determinant of ferroptosis sensitivity