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Other polymorphic deficient class 2 mutations are G6PD Canton, frequent in Southern China and Taiwan
In human thyroid cancer, GPx3 is frequently methylated, and the expression of GPx3 is regulated by methylation of the promoter region, and this methylation is related to tumor size and lymph node metastasis through the inhibition of Wnt/-catenin signaling [100]
The elevation of p21 protein mainly is regulated by post-translational modifications such as phosphorylation or ubiquitylation
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