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In PD, aggregated syn, particularly in its protofibrillar form, impairs proteasome activity, reducing its efficiency in processing both ubiquitinated and nonubiquitinated substrates [166, 167, 168]
Damage to these musculoskeletal entities are typically caused by tears in these fibers during activity
Mol Neurobiol 47:495508 Walker DG, Lue LF, Adler CH, Shill HA, Caviness JN, Sabbagh MN, Akiyama H, Serrano GE, Sue LI, Beach TG (2013) Changes in properties of serine 129 phosphorylated alpha-synuclein with progression of Lewy-type histopathology in human brains
Die Tachykardie kann Stress verursachen, ist belastend (z
