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A highly powered study has shown higher BDNF expression to be associated with slower cognitive decline, even after controlling for the effect of neuropathology 17

During the intermediate and terminal phase of RA-imposed tissue inflammation, tissue-residing macrophages, T cells, B cells and stromal cells are chronically activated and under high metabolic stress, creating a microenvironment poor in oxygen and glucose, but rich in metabolic intermediates, such as lactate

Looking Ahead: From Throughput to Confidence Clinical research enters 2026 shaped by constraint, but guided by clarity