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While Rv2172c shows no significant primary sequence homology with MetF, fold-recognition and structural modeling (Kelley and Sternberg, 2009) reveals a significant match with the crystal structure of MetF from Thermus thermophilus , identifying Rv2172c as an atypical MetF homolog

Weeks 12-16+: optimization and maintenance Beyond the 12-week mark, the rate of change typically slows as the body reaches a new equilibrium