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However, the effects may require repeated treatments for sustained results

3 , 70ra13 (2011)

Interestingly, two well-characterized regulators of hunger and satiety, Agrp and Pomc , were consistently changed in the direction typically observed in hungry mice 24 ( Figure 3C )

The panel agreed that initial treatment should be parenteral for severe cases, while high-dose oral B12 can be considered for maintenance
