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HH is characterized by mutations of the HFE gene, involved in the hepcidin/ferroportin axis, which results in insufficient hepcidin production or, exceptionally, in hepcidin resistance

doi: 10.1111/cns.13779 [DOI] [PMC free article] [PubMed] [Google Scholar] 154.Goldberg EL, Shchukina I, Asher JL, Sidorov S, Artyomov MN, Dixit VD

This is the major cofactor for the key thyroid enzyme 5deiodinase which is what converts T4 into T3

Kumar C, Igbaria A, D'autreaux B, Planson AG, Junot C, et al
