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Other studies have demonstrated that treatment with H1R and H4R antagonists reduces the production of pro-inflammatory cytokine IL-6 [65,66]

doi: 10.1016/j.euroneuro.2012.11.013

following intravenous injection, it accumulates in the lungs while decreasing distribution to other organs (Dilliard et al., 2021)

Leptin directly affects pancreatic -cell gene expression and leads to decrease insulin secretion (Seufert et al., Leptin suppresses the expression of preproinsulin mRNA in pancreatic -cells
