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Simply, GH and IGF1 regulate the process by promoting cell proliferation through janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5) signaling pathway or phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and mitogen-activated protein kinase/extracellular regulated MAP kinase 1/2 (MAPK/ERK1/2) pathways, inducing homologous recombination (HR) or non-homologous end joining (NHEJ) to repair DNA damage and decreasing pro-apoptotic molecules (Bax, caspase3) (Valenciano et al., 2012

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Salah satu dari kurang lebih tujuh reaksi Liver Phase II adalah membentuk intermediasi yang diaktifkan pada Phase I, jadi ini merupakan water soluble terhadap ekskresi ginjal

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