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Biochem Pharm
It randomized 220 outpatients with MDD to 40 mg/day, 80 mg/day, or placebo over 12 weeks, using a sequential-parallel comparison design to improve signal detection
10.1182/blood-2007-03-077792 91
The two values are comparable both from low-receptor-density cAMP assays (Coskun 2022 explicitly used Willard 2020's method), with a small cross-lab offset (~1.2, gauged from native-ligand controls) so treat the ~16 as a ratio rather than an exact multiple
