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For instance, in one 1960s study of intravenous NAD+ for addiction, patients who received a fast IV drip experienced immediate headache and shortness of breath, whereas those given the same dose at a slower drip rate (under ~35 drops/min) had no distress

The broader definition is used in this Review

Owing to the selenoprotein hierarchy, GPx-1 is one of the selenoproteins most readily affected by selenium levels

doi: 10.1016/0196-9781(88)90216-1