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Activated phagocytes like neutrophils and macrophages are a major source of O 2 and other potent oxidants such as those shown in Fig
These species are natural by-products produced by the normal metabolism of oxygen in living organisms
This is too bad because glutathione is a critical antioxidant and detoxification molecule present in all cells
Furthermore, hypothyroid-induced decreases in gastrointestinal motility often clinically present as bloating, constipation, and impaired digestion, which further disrupts microbial stability (Xu et al., 2024)
