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Despite this, there is no conclusive evidence that IGF-1 can modify cardiomyocytes in healthy heart tissue in addition to its observed overexpression (75, 83)

Imbalance can result from gut dysfunction (SIBO, leaky gut), nutrient deficiencies, chronic stress, environmental or dietary triggers, and overburdened detoxification pathways

Cuproptosis and copper deficiency in ischemic vascular injury and repair

Apoptosis, the quintessential programmed cell death process, primarily relies on the caspase family for initiation and is typically characterized by membrane contraction, chromatin concentration and apoptotic body formation (103)