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In a clinical trial up to 104 weeks of treatment, when administered with a sulfonylurea, hypoglycemia (glucose level 5%) of tirzepatide include: Nausea Vomiting Diarrhea Decreased Appetite Constipation Abdominal Pain Dyspepsia Adverse Reactions of tirzepatide include (mounjaro PI): Risk of Thyroid C-cell Tumors [see Warnings and Precautions (5.1)] Pancreatitis [see Warnings and Precautions (5.2)] Hypoglycemia with Concomitant Use of Insulin Secretagogues or Insulin [see Warnings and Precautions (5.3)] Hypersensitivity [see Warnings and Precautions (5.4)] Acute Kidney Injury [see Warnings and Precautions (5.5)] Severe Gastrointestinal Disease [see Warnings and Precautions (5.6)] Diabetic Retinopathy Complications [see Warnings and Precautions (5.7)] Acute Gallbladder Disease [see Warnings and Precautions (5.8)] For more detailed information see above on this website under Contraindications & Precautions or see the Mounjaro PI Mounjaro PI: In monotherapy trials with tirzepatide injection for type 2 diabetes mellitus (T2DM), severe hypoglycemia (requiring the assistance of another person) was not reported in either the treatment group or the placebo group

Future studies incorporating ocular tissue expression datasets, functional genomics, and experimental validation will be essential to clarify the potential role of these genes in POAG pathophysiology