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Specific microbial shifts, such as an increase in Bacteroidetes ovatus following host AKR1D1 loss, can lead to the accumulation of isolithocholic acid (iso-LCA), which suppresses NK cell cytotoxicity and survival, potentially via TGR5 (44)
Numerous metabolites produced by cancer cells, including itaconate, L-kynurenine, lactic acid, and hyaluronic acid, have been demonstrated to activate Nrf2 and play a significant role in regulating the TIME and tumor-TAMs interaction
Nutrients (2021) 13(9):3126
Adiabatic Air Pre-Cooler (Fig
