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The pathogenesis of myelodysplastic syndrome (MDS) and erythropoiesis involve PLC-1/protein kinase C (PKC) signal transduction, especially nuclear PLC-1 gene (94).PLC-1a is a negative regulator of erythroid differentiation, and which is reduced in erythropoietin-responder MDS patients and in normal hematopoietic stem cell progenitors induced to erythroid differentiation (95)
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Alpha lipoic acid Lipoic acid (ALA) is a highly potent sulfur-containing antioxidant with marked health properties
