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Ruptured ferroptotic cells trigger innate immunity by releasing damage-associated molecular pattern molecules (DAMPs), such as heat shock proteins (HSPs) and oxidized lipids, upon tissue damage or tumor therapy ( Composed of B cells, T cells, and their secreted products, adaptive immunity is responsible for recognizing and clearing pathogens or abnormal cells specifically and forming immune memory ( 2.1 Macrophages Macrophages, which form a pivotal element of the innate immune system, are imperative for several facets of inflammatory processes, phagocytosis of debris, and tissue repair ( Figure 2 )

emphasizing the unrestricted effect of riboflavin on homocysteine metabolism despite MTHFR genotypes (91)

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Sadosky A, Mardekian J, Parsons B, Hopps M, Bienen EJ, Markman J (2015) Healthcare utilization and costs in diabetes relative to the clinical spectrum of painful diabetic peripheral neuropathy