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In contrast, in the liver , NNMTderived 1MNAM can actually stabilize SIRT1, potentially exerting beneficial metabolic effects
A deficiency in VitB12 is known also to be associated with an increase in oxidative stress
However, with exposure to stimuli such as oxidative/xenobiotic stress, Nrf2 escapes from Keap1-mediated repression and translocates to the nucleus, where it dimerizes with small musculoaponeurotic fibrosarcoma proteins (sMaf)
