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93 A meta-analysis published in 2004 of findings from randomized placebo-controlled trials found 21.6% of subjects with tinnitus who were given ginkgo improved, while 18.4% of those given placebo improved, a difference that was not statistically significant

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Apart from nicotinamide metabolism adaption during disease relapse or refractory stages, earlier studies have shown the leukemic blasts and LSCs have evolved a complex adaptation of metabolic flexibility through cell intrinsic, partly due to the selection pressure from the chemotherapy and through various microenvironmental mechanisms

10.1016/j.jip.2020.107480 69 WuX.WuT.HuangA.ShenY.ZhangX.SongW.et al (2021)