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This trend is also noticeable when comparing the panels in Supplemental Figure 2 as well as between Figure 9 and Supplemental Figures 35, where most of the original clusters shown in blue remain constant throughout the 4 figures, while the ones that become significant are depicted mainly as red or purple, reflecting a shift from hypometabolism of significant metabolites toward hypermetabolism for newly significantly different metabolites

The gut microbiota metabolizes these nutrients (especially choline and carnitine) and produces TMA

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Phytochem Rev 116 Kimble R, Keane KM, Lodge JK, et al (2022) Polyphenol-rich tart cherries (Prunus cerasus, cv Montmorency) improve sustained attention, feelings of alertness and mental fatigue and influence the plasma metabolome in middle-aged adults: a randomised, placebo-controlled trial