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Among these inhibitors, the TLR4 inhibitor TAK242 exhibits promise in the treatment of inflammatory diseases, including sepsis and acute lung injury, by obstructing the LPSor HMGB1mediated signaling pathways

Mitochondria produce large amounts of ROS through the oxidation-reduction reactions carried out in the respiratory chain.2 Evidence indicates that under physiological conditions, ROS may participate in redox signalling, but excessive ROS production may cause oxidative damage to proteins, lipids and DNA, and affect cellular functionality.3 Several studies indicate the role of oxidative stress in the progression of autoimmune thyroid diseases, such as Graves disease.4 ROS are neutralised by the antioxidant enzymes SOD, CAT, and GPx

High expression of heme oxygenase-1 in target organs may attenuate acute graft-versus-host disease through regulation of immune balance of TH17/Treg

Apoptotic cell counts confirmed that there was significant neuroprotection in CGNs pretreated with Immunocal, decreasing apoptosis by approximately 80% (Figure 4(b))
