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Description
MALE INFERTILITY Research on male factor infertility demonstrates that sperm are vulnerable to reactive oxidative species (ROS) which can result in decreased motility (due to loss of mitochondria ATP production), decreased viability, increased mid-piece morphology, and reduced fertilization (sperm capacitation and acrosome reaction)
These mutations preferentially affect cancer driver genes (e.g., APC and KRAS) and promote chromosomal instability through chromothripsis-like rearrangements
doi: 10.1002/jbmr.3573
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