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In contrast, during acute ethanol exposure, ethanol competes with APAP for Cyp2E1 metabolism, which reduces NAPQI formation as long as ethanol is present and attenuates liver injury [176]

SGLT2 inhibitors selectively target SGLT2 on the surface of the proximal renal tubular lumen, inhibiting glucose reabsorption and promoting urinary glucose excretion [150]

Oral bacteria can colonize the gut when swallowed in large quantities (during oral inflammation or periodontitis), with some strains surviving stomach acid through biofilm protection or inherent tolerance, while preexisting gut inflammation creates a favorable environment for their establishment by reducing microbial diversity and stability (Newman and Kamada, 2022)

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