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Highly sensitive detection technologies, such as Single Molecule Array (SIMOA) enable quantification of low-abundance proteins in fluids like CSF and plasma

Current research implicates several interrelated pathogenic mechanisms, including persistent neuroinflammation, mitochondrial dysfunction [27], excessive production of reactive oxygen species (ROS) [28], reduced dopamine synthesis [8], impaired cerebral glucose metabolism [8], and the accumulation of misfolded -synuclein in the form of Lewy bodies [29]

CSE/H2S system alleviates uremic accelerated atherosclerosis by regulating TGF-/Smad3 pathway in 5/6 nephrectomy ApoE-/- mice

Fipronil is a powerful uncoupler of oxidative phosphorylation that triggers apoptosis in human neuronal cell line SHSY5Y