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Caffeine, however, does increase heart rate and insomnia and can have significant negative health effects, including death, if taken in too high of a dose

[DOI] [PubMed] [Google Scholar] 317.Kogan Y., Sabo E., Odeh M

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Thus, the serine residue at position 114 of NHR-49 and potentially others within the hinge-region of NHR-49 were detected across multiple experiments which used both ectopically overexpressed and endogenously tagged forms of NHR-49
