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Overexpressing of FZD7 activates the oncogenic factor tumor protein 63 (TP63), leading to increased levels of glutathione metabolic pathways, including GPX4, which protects cells against chemotherapy-induced oxidative stress and ferroptosis

1986;64(Suppl 7):4043

476,477 Genetic code reprogramming by substituting endogenous aaRSs for more promiscuous mutants, such as PheRS A294G, LeuRS D345A, and editing deficient ValRS T222P, has also been reported