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Neurochem Res 39:883892 Dringen R, Pfeiffer B, Hamprecht B (1999) Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione

Even more to the point, tumor-associated endothelial cells (TECs) evolve into mesenchymal phenotypic cells by endothelial-mesenchymal transition, which drives various cancerous biological characteristics of tumors, including aberrant angiogenesis, CAF formation, tumor metabolism, invasion, metastasis, and resistance to treatment ( The transformation of ECs into capillaries requires endothelial growth, migration, invasion, and matrix remodeling ( in vitro model and found EGCG might inhibit the tumor vascularization microenvironment of TECs ( In TME, tumor cells typically produce high levels of VEGF, which is essential to support tumor growth and survival