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At the 2-week follow-up period, higher soluble interleukin (IL)-2 receptor-alpha levels and TNF receptor-II levels were also noted in the symptomatic HIV patients on cART, The ratios of pro-inflammatory vs anti-inflammatory cytokines (TNF-/IL-4 and interferon-gamma/IL-10) were significantly in favor of the pro-inflammatory cytokines in the symptomatic patients on cART compared to the asymptomatic patients on cART

After screening 717 articles, three papers [911] reporting four RCTs that involved 523 patients were proved eligible

However, previous reviews emphasize common mechanistic pathways such as inflammation and oxidative stress while emerging pathways particularly autophagy-related signaling are under explored

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