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Another pathway of interest is the serine biosynthesis axis, centered on the phosphoglycerate dehydrogenase (PHGDH), which diverts glycolytic intermediates to produce serine [144]

Advanced glycation end products accelerate calcification in VSMCs through HIF-1/PDK4 activation and suppress glucose metabolism

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doi: 10.1016/j.bcp.2005.01.024
