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[15] Therefore, high doses of biotin (in the tens or hundreds of milligrams) are generally reserved for research settings or specific medical conditions like certain metabolic disorders or experimental therapies (e.g., very high-dose biotin has been investigated in multiple sclerosis)

PMID 9562034

NHS and SPS guidance discourages multi-dose vial use outside of specific, policy-governed circumstances

Jastreboff PJ
