nnmt gene variants rsid 5-amino-1mq Comment βcuriousβ for the full newsletter. π There's a new metabolic regulator making waves. In preclinical studies, it: β grip strength ~40%, β muscle size, β endurance, β fat mass It may Selective and membrane-permeable small molecule
Description
The digestive bypass ensures they receive therapeutic B12 levels regardless of gut health status

Gil Alabarse, P., Chen, L

5-Amino-1MQ is an orally bioavailable, cell-permeable small molecule that potently inhibits NNMT (nicotinamide N-methyltransferase), the enzyme responsible for methylating nicotinamide to 1-methylnicotinamide (1-MNA)

Research hasn't shown a meaningful clinical difference in absorption between methylcobalamin and cyanocobalamin for most people
