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In Japan, a case of congenital hypothyroidism of central origin was identified in 1:160,000 live newborns using neonatal screening programs for hypothyroidism based on a cohort of babies with TSH or T4 readings falling in the hypothyroid range [13, 14]

Vivid dreams occasionally reported, likely related to enhanced melatonin secretion and deeper sleep architecture

Hormonal birth control: Other GLP-1 medications have been shown to potentially decrease the efficacy of oral birth control pills

Both agencies emphasize the need for well-controlled studies, pharmacovigilance plans, and clear evidence of benefit over risk