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Theranostics 10:1141611427
Insert the needle : Hold the pen at a 90-degree angle to the skin surface, as recommended by FIT UK
At the ultrastructural level, irregular and immature elastin fibers and fibers devoid of microfibrils were observed. These findings suggested that both elastic fiber abnormalities and reduced collagen content contribute to the clinical features seen in patients with clEDS. There were no consistent electron microscopy (EM) findings in the ten patients in our cohort who had EM performed
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