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PRP also suppresses the nuclear factor-kappa B (NF-B) pathway in macrophages, leading to decreased production of pro-inflammatory cytokines and mitigation of local inflammation [98, 99]
doi: 10.1016/j.ecl.2010.02.007, 41
This pathway can be inhibited by the cell-survival signaling pathways mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K)/Akt (protein kinase B), which may protect the cells against the cytotoxic effects of VPA [210]
