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2.20 Danio rerio (zebrafish) models insights into Alzheimers disease research The zebrafish ( Danio rerio ) has emerged as an indispensable model organism for studying neurodegenerative diseases, including AD (Shenoy et al., 2022)
Dong, Y
It is proposed that the dimeric KEAP1 captures NRF2 first through the ETGE motif, which has 100-fold more affinity to KEAP1, followed by DLG motif docking onto the other Kelch repeat domain
However, these effects were observed only in the intention-to-treat analysis, not the per-protocol population
