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The homocysteine (Hcy) dependent trans-sulfuration pathway is responsible for maintenance of the intracellular glutathione pool and regulation of this pathway under oxidative stress (Fig 1)

Scientific research primarily focuses on anti-aging and longevity studies, cellular stress response mechanisms, telomerase activation, and potential treatments for age-related diseases

Toxicol Sci 95(1):156162

Based on domain architecture comparison with HNF4 58,59 , we engineered an NHR-49 truncation (295422) to disrupt ligand binding by removing a majority of the ligand binding domain, while retaining its analogous N-terminal, DNA-binding, hinge, and C-terminal domains (Fig