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The practical result: a circulating half-life of roughly 20-30 hours versus minutes for the native compound

Wound Healing and Tissue Remodeling The peptide's role in wound healing is particularly impressive

A follow-up study in 2007 found significant dose-related increases in malignant tumors in some of the rats

Moreover, these molecular changes were accompanied by a phenotypic switch in macrophage polarization, favoring the anti-inflammatory M2 subset over the pro-inflammatory M1 phenotype (Liu et al., 2025)
