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13,14 The late 1970s and 1980s saw the development of new experimental techniques that revolutionized protein folding research

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Antioxidant Effect of O 3 The first O 3 antioxidant effects were explored by the studies of Boccis group showing that, by using doses below the threshold of the O 2 -O 3 therapeutic window, i.e., below the concentration of 80 g/ml, whole blood was protected from hemolysis and its reactivity was controlled for about 20%40% by the antioxidant system of the plasma, avoiding the toxic effects observed at higher concentrations, such as those detected in erythrocytes (lipid peroxidation, methemoglobin levels, hemolysis