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doi: 10.3390/antibiotics6040021 189 KrebsB

Initially, it was thought that hyperthermia aids radiotherapy primarily by enhancing oxygen delivery to tumors, thus reducing radiation-resistant hypoxia, supported by refs

these macrophages take up the modified lipoprotein and then transform into foam cells ( The microenvironment in fatty streak and intermediate lesions contains high levels of oxidized lipids and there is significant inflammatory activity occurring within this environment, both of which enhance the formation of lipid hydroperoxides ( Advanced plaque core: hypoxia, nutrient constraint, and execution permissiveness Advanced plaque formation occurs when oxygen diffusion becomes limited due to increased intimal thickness and enhanced metabolic activity of macrophages

Interestingly, this effect is augmented by the presence of hyperglycemia, indicating that comorbid diabetes may enhance the proatherogenic phenotype of G6PD-d