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10.3390/ijms26062691 [DOI] [PMC free article] [PubMed] [Google Scholar] Beard JR, Officer A, Carvalho IA, Sadana R, Pot AM, Michel JP, Lloyd-Sherlock P, Epping-Jordan JE, Peeters GM, Mahanani WR, Thiyagarajan JA, Chatterij S (2016) The world report on ageing and health: a policy framework for healthy ageing

From a translational perspective, prioritized next steps include well-designed pharmacokinetic and toxicology studies, reproducible efficacy assessments across models, and early-phase clinical trials that emphasize safety and tolerability