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The experiment adhered to ARRIVE guidelines and the ethical guidelines of Jilin University and national regulations regarding the welfare of experimental animals, ensuring that the animals had access to water and food

4-week titration

After weekly intravenous injection of 100 g MHCI- or MHCII-binding K71 or K31 peptides, the mean AA affected area was significantly decreased

Not only in tissue homogenates, as used in our study, including a contribution of both, extracellular and intracellular components, but increased Glu/GABA ratio was also observed by HPLC when monitoring neurotransmitters in interstitial fluid by analyzing microdialysate by Zeng et al., in rats after middle cerebral artery occlusion (MCAO) in the first 130 minutes after onset of ischemia (Zeng et al