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Topical retinoids like adapalene thin the outer skin and can increase peel penetration and irritation, so most protocols pause them for several days to about a week before a peel and resume once the skin recovers

In septic lung injury, elevated lactate levels exacerbate alveolar epithelial cell ferroptosis through lactylated histone H3 lysine 18 (H3K18la)-mediated upregulation of METTL3, which enhances m6A modification of ACSL4, ultimately contributing to the development of acute respiratory distress syndrome (82)