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Adipose tissue heterogeneity: implication of depot differences in adipose tissue for obesity complications

Cytochrome c binds apoptosis protease activating factor 1 (APAF1) leading APAF1 to oligomerise into a heptameric structure called the apoptosome that activates initiator caspase-9
This reciprocal association between insulin and GH and its potential implications for normal substrate metabolism was initially described by Rabinowitz & Zierler (105)
