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NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development

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facilitating over-stimulated or sustained inflammatory responses with interferon and cytokine release, influencing ROS production, iron storage, platelet coagulability, cytokine production stimulation, regulation of fission and fusion, mitochondrial biogenesis, and interference of apoptosis and mitophagy (312319)

studied human females and found that GPX mRNA was 134% higher in menstruating females than after ovariectomy [1]