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Correspondingly, MAPK has four classical signal pathways, among which, ERK pathway is the most classical MAPK signal pathway, critical in DKD development
E., Liu, Y
M.NezG.et al (2013)
Upon activation, they polarize into either M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotypes, exerting contrasting effects on neuronal survival (365)
