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Description
For example, cellular senescence, classified as an antagonistic/secondary hallmark of aging, results as a consequence of persistent DNA and/or proteomic damage (primary hallmarks) that drives integrative hallmarks such as chronic inflammation and altered intracellular signaling, which further perpetuate other aging hallmarks
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All inhibitors maintain interactions between the acetamide carbonyl oxygen with the oxyanion hole of the enzyme
Ageing Res Rev 46: 3241, 2018
