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However, overexpression of HIF-1 markedly attenuated these effects of irisin
The precise regulation of Drp1 is vital for cellular health, as excessive activation of Drp1 under pathological conditions triggers mitochondrial fission and the release of cytochrome c, ultimately leading to apoptosis [129]
Reelin/RELN activates Rap1 to regulate actin cytoskeleton reorganization (via N-cofilin phosphorylation) and neuronal polarity, and promotes epithelial-mesenchymal transition by downregulating E-cadherin
