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Gonzalez et al
Cardiac and skeletal muscle: TB-500 has been studied in post-infarct cardiac remodeling, where it promotes epicardial progenitor migration and reduces fibrosis in murine models (Smart et al., 2007)
It matters because a small molecule behaves differently from a peptide in dosing, stability, and how it is studied
Still, where some see a promising drug, others see big claims backed by little evidence
