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Fibroblast activation and proliferation, extracellular matrix (ECM) modifications, angiogenesis and vascular remodeling, and airway smooth muscle (ASM) proliferation and hypertrophy are among the alterations in the subepithelial structure of the airways ( X e , airway remodeling can also be sensitively measured ( In recent years, an overlap phenomenon has been observed in asthma and COPD, where symptoms are similar to those of COPD but respond significantly to bronchodilators, called asthma-COPD overlap (ACO)

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Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis